We proudly announce Prof. Dr. Christian Hackenberger (Leibniz-Forschungsinstitut für Molekulare Pharmakologie – Berlin) as key-note lecturer. His work focusses on studying protein modifications that control many signaling pathways that support healthy functioning and that are disrupted in disease. Such modifications can act as “toggle switches” between health and disease. Chemical biologists want to control these protein modifications in the cell, both to study the biological role of such modifications and to decorate proteins with fluorescent moieties that permit their visualization. His laboratory aims to identify new chemical approaches that allow the modification of peptides and proteins, both on isolated biomolecules as well as in living cells and organisms. Here, the main objective is to apply these highly selective bioconjugation reactions to study the functional consequences of natural protein modifications, as well as to generate novel pharmaceutical and medicinal applications, such as protein or antibody-drug conjugates (ADCs) against cancer or viral infections.

We look forward to hearing and discussing the latest advances in peptide chemistry and highly encourage all PhD-students and PostDocs to engage and present their latest results in the form of a poster. ChemBioChem endorses a poster prize for the best poster presentation.!

Program Dutch Peptide Symposium – 21st April 2023 –Leiden (NL)

9.30 – 10.00Registration / Coffee & Tea
10.00 – 10.05Welcome and opening
10.05 – 10.25Ned Buijs – Leiden University – Institute of Biology
Next Generation Bacitracins: Using rational design to improve a classic antibiotic
10.25 – 10.45Stijn Agten – Maastricht University – Cardiovascular Research Institute Maastricht
Effects of vitamin-K dependent proteins on vascular calcification
10.45 – 11.05Aimee Boyle– Leiden University – Leiden Institute of Chemistry
Selective binding of transition metal ions in self-assembling helical peptide scaffolds
11.05 -11.30 Coffee break
11.30 – 11.50Sebastian Pomplun– Leiden University – Leiden Academic Centre for Drug Research
Engineering bioactive dimeric transcription factor analogs to inhibit MYC dependent gene programs in cancer
11.50 – 12.10Leendert van den Bos – EnzyTag b.v.
Selected Examples on the Use of Chemo-Enzymatic Peptide Synthesis
12.10 – 12.40Andrew Jamieson – University of Glasgow– Advanced Research Centre (UK)
Development of bifunctional, Raman active diyne-girder stapled α-helical peptides
12.40 – 13.50Lunch and poster session
13.50 – 14.10Stephan Hacker – Leiden University – Leiden Institute of Chemistry
Covalent Inhibitors for the Proteome-wide Identification of New Druggable Targets for Antibiotics
14.10 – 14.30Peter ‘t Hart – Max Planck Institute of Molecular Physiology Dortmund (DE)
Development of Macrocyclic PRMT5 Adaptor Protein Interaction Inhibitors
14.30 – 15.00Ranganath Gopalakrishnan –AstraZeneca – Gothenburg (SE)
Different applications of Peptide drug discovery: From Late stage functionalization to Chemical Biology tools
15.00 – 15.25Coffee break
15.25 – 15.45Sven Wijngaarden – Leiden University – Leiden Institute of Chemistry
Synthetic and chemoenzymatic approaches to investigate Asp/Glu-ADP-ribosylation
15.45 – 16.05Kevin Neumann – Radboud University Nijmegen– Institute for Molecules and Materials
Combining click, trans-click and de-click: Traceless and efficient modification of biomolecules enabled by
16.05 – 16.55Christian Hackenberger – Leibniz Institute for Molecular Pharmacology – Berlin (DE)
Next-generation bioconjugates for intra- and extracellular targeting
16.55 -17.00Closing remarks – Poster prize
17.00 – 18.00Drinks