Program
We proudly announce Prof. Dr. Christian Hackenberger (Leibniz-Forschungsinstitut für Molekulare Pharmakologie – Berlin) as key-note lecturer. His work focusses on studying protein modifications that control many signaling pathways that support healthy functioning and that are disrupted in disease. Such modifications can act as “toggle switches” between health and disease. Chemical biologists want to control these protein modifications in the cell, both to study the biological role of such modifications and to decorate proteins with fluorescent moieties that permit their visualization. His laboratory aims to identify new chemical approaches that allow the modification of peptides and proteins, both on isolated biomolecules as well as in living cells and organisms. Here, the main objective is to apply these highly selective bioconjugation reactions to study the functional consequences of natural protein modifications, as well as to generate novel pharmaceutical and medicinal applications, such as protein or antibody-drug conjugates (ADCs) against cancer or viral infections.
We look forward to hearing and discussing the latest advances in peptide chemistry and highly encourage all PhD-students and PostDocs to engage and present their latest results in the form of a poster. ChemBioChem endorses a poster prize for the best poster presentation.!
Program Dutch Peptide Symposium – 21st April 2023 –Leiden (NL)
9.30 – 10.00 | Registration / Coffee & Tea |
10.00 – 10.05 | Welcome and opening |
10.05 – 10.25 | Ned Buijs – Leiden University – Institute of Biology |
Next Generation Bacitracins: Using rational design to improve a classic antibiotic | |
10.25 – 10.45 | Stijn Agten – Maastricht University – Cardiovascular Research Institute Maastricht |
Effects of vitamin-K dependent proteins on vascular calcification | |
10.45 – 11.05 | Aimee Boyle– Leiden University – Leiden Institute of Chemistry |
Selective binding of transition metal ions in self-assembling helical peptide scaffolds | |
11.05 -11.30 | Coffee break |
11.30 – 11.50 | Sebastian Pomplun– Leiden University – Leiden Academic Centre for Drug Research |
Engineering bioactive dimeric transcription factor analogs to inhibit MYC dependent gene programs in cancer | |
11.50 – 12.10 | Leendert van den Bos – EnzyTag b.v. |
Selected Examples on the Use of Chemo-Enzymatic Peptide Synthesis | |
12.10 – 12.40 | Andrew Jamieson – University of Glasgow– Advanced Research Centre (UK) |
Development of bifunctional, Raman active diyne-girder stapled α-helical peptides | |
12.40 – 13.50 | Lunch and poster session |
13.50 – 14.10 | Stephan Hacker – Leiden University – Leiden Institute of Chemistry |
Covalent Inhibitors for the Proteome-wide Identification of New Druggable Targets for Antibiotics | |
14.10 – 14.30 | Peter ‘t Hart – Max Planck Institute of Molecular Physiology Dortmund (DE) |
Development of Macrocyclic PRMT5 Adaptor Protein Interaction Inhibitors | |
14.30 – 15.00 | Ranganath Gopalakrishnan –AstraZeneca – Gothenburg (SE) |
Different applications of Peptide drug discovery: From Late stage functionalization to Chemical Biology tools | |
15.00 – 15.25 | Coffee break |
15.25 – 15.45 | Sven Wijngaarden – Leiden University – Leiden Institute of Chemistry |
Synthetic and chemoenzymatic approaches to investigate Asp/Glu-ADP-ribosylation | |
15.45 – 16.05 | Kevin Neumann – Radboud University Nijmegen– Institute for Molecules and Materials |
Combining click, trans-click and de-click: Traceless and efficient modification of biomolecules enabled by Tetrazine-Thiol-Exchange | |
Key-note: | |
16.05 – 16.55 | Christian Hackenberger – Leibniz Institute for Molecular Pharmacology – Berlin (DE) |
Next-generation bioconjugates for intra- and extracellular targeting | |
16.55 -17.00 | Closing remarks – Poster prize |
17.00 – 18.00 | Drinks |